老年人的饮食模式,炎症生物标志物和认知:对三个基于人口的队列的分析
Natalia Ortega1, Leona Schütte2, Tosca O E de Crom3
1Institute for Primary Health Care (BIHAM), University of Bern, Bern, Switzerland; Population Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland; Graduate School for Health Sciences, University of Bern, Bern, Switzerland.
Clinical nutrition (Edinburgh, Scotland)
|September 5, 2024
概括
消费炎症饮食模式 (IDP) 并没有显著影响老年人的认知功能. 这项研究发现,在5年时间内,内在流离失所者与认知能力下降之间没有有意义的关联.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 认知神经科学 认知神经科学
背景情况:
- 预防认知能力下降对于老龄化人口至关重要.
- 某些饮食可以通过减少炎症来减缓认知衰退.
- 炎症性饮食模式 (IDP) 对认知的影响需要进一步研究.
研究的目的:
- 为了确定炎症饮食模式 (IDPs) 对认知功能的影响.
- 随着时间的推移,分析三大基于人口的队列中的认知变化.
- 评估IDP消费与55岁以上个体认知衰退之间的关联.
主要方法:
- 三个队列的纵向分析 (加拿大老龄化纵向研究,科拉斯下载PsyCoLaus,鹿特丹研究).
- 使用基于炎症标志物的降低等级回归来导出IDPs.
- 带有逆概率权重的边际结构模型,在至少3年的随访期间评估认知结果 (一般和特定领域).
主要成果:
- 10,366名参与者 (平均年龄68岁) 接受了平均5年的随访.
- 饮食只解释了1-2%的炎症标志物的变化.
- 在高和低IDP消费组之间没有观察到一般或特定领域认知功能的显著差异.
结论:
- 炎症饮食模式解释了炎症标志物变化的很小比例.
- 消费IDPs没有显示与认知功能或下降的关联.
- 目前的证据不支持国内流离失所者在老龄化人口中调节认知轨迹方面的作用.
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