使用神经网络的 gabapentinoid 处方模式和预测器:在 2012 年至 2021 年期间,在全国各地的急救部门进行了分析
Christine Ramdin1, Emily Chen2, Lewis S Nelson1
1Department of Emergency Medicine, Rutgers New Jersey Medical School, USA.
The American journal of emergency medicine
|September 5, 2024
概括
从2012年到2021年,加巴丁类药物处方在急诊室显著增加. 与阿片类药物的联合处方保持稳定,但由于滥用问题,加巴丁类药物的使用增加需要进一步调查.
科学领域:
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 加巴丁类药物越来越多地用于神经病痛,可能作为阿片类药物的替代品.
- 人们对 gabapentinoid 的滥用和过量服用存在担忧,通常与其他物质一起使用.
- 这项研究调查了在急诊室 (ED) 中 gabapentinoid 处方的国家趋势.
研究的目的:
- 确定从2012年到2021年在ED释放时处方 gabapentinoid 的国家趋势.
- 分析 gabapentinoid 和阿片类药物联合处方的趋势.
- 确定阿片类药物与 gabapentinoids 联合处方的关键预测因素.
主要方法:
- 追溯分析国家医院门诊医疗调查 (NHAMCS) 数据 (2012-2021年).
- 检查了在ED释放时 gabapentinoid处方的趋势.
- 利用描述性统计和相关性分析;神经网络识别了阿片类药物共同处方的预测因素.
主要成果:
- 在ED出院时, gabapentinoid的处方从2012年的0.1%上升到2021年的0.63%.
- 在27.2%的 gabapentinoid处方中出现了阿片类药物的联合处方,随着时间的推移没有显著变化.
- 普雷加巴林处方显示线性增加;替代提供者,保险,年龄和地区预测了阿片类药物联合处方.
结论:
- 尽管对滥用和过量服用的担忧,但在ED释放时开处方的 gabapentinoid 显著增加.
- 虽然可能比阿片类药物更安全,但 gabapentinoid 处方的增加需要监测滥用.
- 需要进一步的研究,以了解和减轻与加大 gabapentinoid 使用相关的风险.
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