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变化的带状子子子区域功能连接在慢性失眠障碍中与焦虑

Hongyu Zhang¹, Zeran Zhao², Shang Zhang³

¹Chengdu Medical College, Department of Neurology, Chengdu Second People's Hospital, Chengdu, Sichuan, 610500, China.

|September 5, 2024

概括

慢性失眠障碍 (CID) 与焦虑表现出明显的环状回膜 (CG) 功能连接 (FC) 改变. 这些大脑网络的变化可以作为区分CID亚型的生物标志物.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

慢性失眠障碍 (CID) 经常与情绪障碍同时发生.
带带回 (CG) 涉及到CID和焦虑的病理生理学.
在患有焦虑症的CID中,CG功能连接 (FC) 的具体变化尚不清楚.

研究的目的:

研究患有CID个体的CG功能连接 (FC) 特性,区分患有焦虑症和没有焦虑症的人.
为了确定与慢性失眠中的焦虑相关的潜在神经网络差异.

主要方法:

休息状态功能磁共振成像 (fMRI) 用于92名患有CID和36名健康对照 (HC) 的个人.
患有CID的参与者被分为有焦虑的CID (CID-A) 和没有焦虑的CID (CID-NA) 组.
人类脑组图谱被用来构建和分析亚区域CG FC网络.

主要成果:

与HC相比,CID患者表现出前,中额前 (MFG) 和海马体的CG FC降低,以及中/上前 (MTG/STG) 的FC增加.
与CID-NA相比,CID-A患者的突出和默认模式网络的CG FC降低,与thalamus和MFG的FC增加.
CG FC模式可以以84.21%的准确度对CID-A和CID-NA进行分类,CG FC到MFG,乳腺体和面是关键的区分因素.

结论:

在CID与焦虑中,在CG次区域的大脑网络中发现了特定的变化.
这些CG FC变化可以作为CID亚型的早期检测和区分的潜在生物标志物.
了解这些网络变化有助于区分CID与焦虑和其他形式的慢性失眠.

关键词:

焦虑焦虑是一种焦虑.环状回形 (cingulated gyrus) 是一个有环状回形的.功能连接性的功能连接性.失眠障碍是一种失眠障碍.机器学习是机器学习.

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