在Chromochloris zofingiensis中具有不同功能群的双的毒理作用,吸收和生物降解
Ziyue Zhang1, Min Gao1, Yaqi Xu1
1Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Collaborative Innovation Center for Eco-Environment, Hebei Research Center of the Basic Discipline of Cell Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China.
Journal of hazardous materials
|September 5, 2024
概括
双 (BPs) 上的功能组显著改变了它们在微藻中的毒性和生物降解. 化BP会导致更大的细胞损伤和压力,影响光合作用并积累细胞成分.
科学领域:
- 环境毒理学环境毒理学
- 藻类生物学 藻类生物学
- 生物化学 生物化学
背景情况:
- 双 (BPs) 是广泛使用的内分泌干扰化合物.
- 不同功能组的BP的不同毒性和降解机制尚不清楚.
研究的目的:
- 为了比较四种双 (BPA,BPS,BPAF,TBBPA) 对光合作用微藻Chromochloris zofingiensis的毒性影响.
- 研究BP上的不同功能组如何影响其毒性,细胞吸收和生物降解途径.
主要方法:
- 在Chromochloris zofingiensis.四个BP的比较毒性评估.
- 测量细胞吸收,氧化应激,光合作用效率以及粉和脂质的积累.
- 转录组分析以确定差异表达基因 (DEG) 和关键调节通路.
主要成果:
- 与含有素的BP (TBBPA,BPAF) 相比,含有素的BP的细胞吸收率更高,氧化应激增加,光合作用效率降低,粉/脂质积累更大.
- 比起BPAF,TBBPA的毒性更高,可能是由于不完全脱.
- 转录组分析显示了不同BP的独特基因表达模式,其中化BP诱导更多的DEGs.
- 在BP中观察到参与内细胞结合,过氧体和ER蛋白处理的基因的升级,而与光合作用相关的基因表现出不同的反应.
结论:
- 功能组对微藻中双的毒性和生物降解具有关键影响.
- 化增加双毒性,改变细胞反应,强调化学结构在环境风险评估中的重要性.
- SIN3A,ZFP36L,CHMP和ATF2被确定为Chromochloris zofingiensis.在双毒性通路中的潜在关键调节者.
相关概念视频
01:26Toxic Reactions: Overview
958
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
958
01:36Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
01:16Drug Biotransformation: Overview
2.4K
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
2.4K
01:19Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems
156
Phase I biotransformation reactions are integral to drug metabolism, predominantly involving oxidative, reductive, and hydrolytic transformations. Chief among these are oxidative reactions, which enhance the hydrophilicity of xenobiotics and introduce polar functional groups to facilitate their elimination from the body.
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
156