血清能系统中的遗传变异对功能神经障碍症状严重程度和临床结果的影响
Samantha Weber1, Lucía Trinidad Rey Álvarez2, Juan Ansede-Bermejo3
1Department of Neurology, Psychosomatic Medicine Unit, Inselspital Bern University Hospital, University of Bern, 3012 Bern, Switzerland; University of Zurich, Psychiatric University Hospital Zurich, Department of Psychiatry, Psychotherapy and Psychosomatics, 8032 Zurich, Switzerland.
Journal of psychosomatic research
|September 5, 2024
概括
功能神经障碍 (FND) 症状严重程度和结果受到基因对基因相互作用的影响. 色素路径中的特定基因变异可能会使个体易患FND并影响治疗反应.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
背景情况:
- 功能神经障碍 (FND) 是一组复杂的疾病,影响大脑功能.
- 了解FND的遗传基础对于预测症状严重程度和临床结果至关重要.
- 基因-环境和基因-基因相互作用被假设在FND病变发生过程中起作用.
研究的目的:
- 在功能神经障碍 (FND) 中研究基因环境和基因基因相互作用.
- 确定这些相互作用对FND症状严重程度和临床结果的影响.
- 确定可能预测FND患者临床轨迹的遗传风险因素.
主要方法:
- 在七个与压力相关的基因中,对85名混合FND患者进行了基因定型,以寻找10个单核酸多态 (SNP) 基因.
- 评估了基因型和FND症状 (临床全球印象得分,发病年龄) 之间的交叉截面关联.
- 在8个月的随访后,对52名患者的基因型和临床结果之间的关联进行了纵向评估.
主要成果:
- 在TPH1 rs1800532和症状严重程度之间发现了名义关联,小等位基因携带者表现出更严重的症状.
- TPH1基因型与临床结果相关,主要等位基因携带者表现出改善结果的趋势.
- 对于TPH2和OXTR在症状严重程度方面,以及对TPH1,TPH2和BDNF在临床结果方面,发现了显著的基因相互作用.
结论:
- 功能神经障碍 (FND) 可能是风险基因易感的复杂相互作用的结果.
- serotonergic 途径中的基因及其相互作用似乎有助于 FND 症状和结果.
- 这些发现凸显了基因分析在理解FND异质性和预测患者轨迹方面的潜力.
相关概念视频
Human Genetics
549
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
549
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
520
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
520
Biological Causes of Schizophrenia
51
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
51
Drugs Affecting Neurotransmitter Synthesis
1.3K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.3K
Depressive Disorders: Etiology
59
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
59
Antidepressant Drugs: MAOIs and Other Agents
205
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
205


