甲状腺激素系统破坏了鱼类中复素的潜力
Imke Van Dingenen1, Emma Andersen2, Sina Volz2
1Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Wilrijk 2610, Belgium.
Ecotoxicology and environmental safety
|September 5, 2024
概括
在斑马鱼胚胎中,Resorcinol暴露破坏了甲状腺激素水平和游泳膀发育的受损. 新的机制,包括甲状腺激素受体对抗性,解释这些效应,突出强调resorcinol.
科学领域:
- 环境毒理学环境毒理学
- 内分泌学 在内分泌学.
- 发育生物学是发展生物学.
背景情况:
- 干扰甲状腺激素 (TH) 系统的环境污染物对人类和环境健康构成风险.
- 树脂是一种内分泌干扰剂,已知可以抑制甲状腺氧化酶 (TPO),一种对TH合成至关重要的酶.
- 有限的生态毒理学数据存在于鱼类中树脂醇的作用,特别是关于甲状腺激素系统干扰 (THSD).
研究的目的:
- 为了研究斑马鱼eleutheroembryo中resorcinol的潜在THSD影响.
- 评估复醇对TH水平,游泳膀膨胀和眼睛形态的影响.
- 为了确定由复素诱导的THSD的新机制.
主要方法:
- 斑马鱼的11个胚胎被暴露在Resorcinol中.
- 评估了甲状腺激素水平,游泳膀膨胀和眼睛形态.
- 进行了体外测试,以确定额外的THSD机制.
主要成果:
- 在斑马鱼胚胎中,Resorcinol暴露显著降低了甲状腺素 (T4) 水平.
- 在受精后5天 (dpf) 游泳膀膨胀受损,与最初的假设相反.
- 没有观察到对眼睛形态的影响.
- 确定了两种新的THSD机制:甲状腺激素受体 (TR) 抗性和TTR结合抑制.
结论:
- 雷索西诺在斑马鱼中表现出THSD潜力,影响TH水平和游泳膀发育.
- 观察到的效应可以通过新发现的机制来解释:TR对抗和TR结合抑制.
- 这项研究增强了对复醇生态毒理学影响和THSD机制的理解.
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