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相关概念视频

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

329
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
329

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相关实验视频

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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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微气泡增强的皮肤间药物输送 电磁贴片 电磁贴片

Xinyue Zhang1, Yihe Zhang1, Yao Chen1

  • 1Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources, Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing 100083, People's Republic of China.

ACS applied materials & interfaces
|September 5, 2024
PubMed
概括
此摘要是机器生成的。

这项研究介绍了一种创新的透皮药物输送贴片,该贴片使用超声波能量产生电力,显著提高了药物透率. 与传统方法相比,这种新的方法可以将药物的血液度提高100%以上.

关键词:
毒品的透 毒品的透疼痛管理 疼痛管理有治疗效果的治疗效果.通过皮肤贴片的贴片.超声波的能量是超声波的能量.

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科学领域:

  • 生物医学工程 生物医学工程
  • 材料科学 材料科学 材料科学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 通过皮肤递送药物提供方便,但由于依赖被动扩散,往往效率低.
  • 超声波增强的透皮传递显示出希望,但由于贴片内的能源利用效率低下而受到限制.
  • 现有的方法缺乏足够的药物透,需要优化以获得有效的治疗结果.

研究的目的:

  • 开发一种用于增强药物输送的新型皮肤贴片.
  • 改进超声波能量转化和利用,用于通过皮肤输送药物.
  • 研究超声波,电场和药物特性对输送疗效的综合影响.

主要方法:

  • 开发一种包含微小气囊和压电软结构的透皮贴片.
  • 在贴片内将超声波能量转化为电能的整合.
  • 在动物实验中使用止痛模型评估药物递送效率.

主要成果:

  • 该贴片有效地将超声波能量转化为电能,增强药物流动.
  • 超声压力和电场的协同作用显著改善了透皮输送.
  • 动物研究表明,与仅用超声波输送相比,药物血液度增加了100%.

结论:

  • 与现有方法相比,开发的透皮贴片显示出更高的药物输送效率.
  • 交付性能可以根据超声波功率,空气口袋大小和药物特征进行调整.
  • 该贴片保持安全的操作温度,并使用热色变化进行有效的超声波贴片匹配.