嗅觉球泡中的饥饿信号主要是探索,寻找食物和周围代谢
Romana Stark1, Harry Dempsey1, Elizabeth Kleeman2
1Monash Biomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, Victoria, Australia.
嗅球中的格林林受体增强了嗅觉功能,特别是在饥饿时. 这改善了食行为,并启动了摄取食物的新陈代谢.
科学领域:
- 神经科学是一个神经科学.
- 代谢过程中的代谢.
- 嗅觉系统是一种嗅觉系统.
背景情况:
- 代谢状态影响嗅觉功能,但机制尚不清楚.
- 格林受体 (GHSR) 在嗅球 (OB) 中的作用尚不清楚.
研究的目的:
- 在OB中调查嗅觉功能的GHSR.
- 评估对食行为和新陈代谢的影响.
主要方法:
- 缺乏OB GHSRs (OB GHSR删除) 的小鼠接受了行为和代谢分析.
- 分析了OB单细胞RNA测序和空间转录组学.
主要成果:
- OBGHSR删除损害了嗅觉的歧视和习惯.
- 减少探索性行为和增加焦虑/抑郁类行为,特别是在禁食时.
- 体重增加,脂肪量增加和葡萄糖代谢受损.
- 确定了OB区域的GHSR+谷氨酸神经元;它们的切除模仿了OBGHSR删除效应.
结论:
- OB GHSRs维持嗅觉功能,特别是在饥饿的时候.
- 促进在压力环境中寻找食物的行为适应.
- 食物消费的主要代谢途径.
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