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基于lentinan的pH响应纳米粒子实现了瘤的组合疗法

Zhen Lin¹, Fan Nie¹, Ruyu Cao¹

¹State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.

International journal of biological macromolecules

|September 5, 2024

概括

这项研究开发了一种结合基因斯坦 (GEN) 和丁 (LTN) 的新型纳米粒子,用于增强癌症治疗. GEN@LTN-BDBA纳米粒子有效抑制瘤生长并刺激抗瘤免疫力.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症研究癌症研究

背景情况:

癌症需要先进的治疗策略,结合化学疗法和免疫疗法显示出有前途.
基因斯坦 (GEN) 是一种具有抗瘤细胞毒性的天然植物化学物质.
伦丁南 (LTN) 是一种天然的多糖,以其在癌症治疗中增强免疫力的特性而闻名.

研究的目的:

构建一个响应pH的纳米粒子,GEN@LTN-BDBA,整合化疗 (GEN) 和免疫疗法 (LTN).
使用in silico模拟研究GEN@LTN-BDBA的形成机制.
为了评估GEN@LTN-BDBA在体外和体内抗癌功效.

主要方法:

对pH反应的GEN@LTN-BDBA纳米颗粒的制造和表征.
在模拟中探索纳米粒子形成机制.
使用A549和HepG2细胞系进行体外细胞增殖试验.
在体内实验以评估瘤抑制和转移预防.

主要成果:

GEN@LTN-BDBA纳米颗粒显著抑制了A549和HepG2细胞增殖.
在体内研究显示,瘤质量显著减少,并预防转移.
GEN诱导了瘤细胞的氧化应激和亡,而LTN促进了树突细胞的成熟和抗瘤免疫反应.

结论:

GEN@LTN-BDBA纳米粒子为增强癌症治疗提供双重化疗和免疫治疗方法.
这项研究提出了一种新的策略,用于将天然化合物结合成纳米粒子,以提高治疗效率.
该制造方法可适应其他多糖和疏水性化疗剂,为新型组合疗法铺平了道路.

关键词:

癌症组合疗法是癌症的综合疗法.化疗化疗是一种化学疗法.杰尼斯泰因 (Genistein) 是一种植物性物质.免疫治疗是一种免疫疗法.伦丁的时间很长.对于pH的响应性

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