相关实验视频

Updated: Jun 14, 2025

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

化疗诱导的认知障碍和质细胞:对化学大脑的新看法

Maria Barbosa-Azevedo¹, Ana Dias-Carvalho¹, Félix Carvalho¹

¹Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal; UCIBIO - Applied Molecular Biosciences Unit, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

Toxicology and applied pharmacology

|September 5, 2024

概括

质细胞,不仅仅是神经元,可能会导致化疗诱导的认知功能障碍,或"化学大脑". 进一步的研究至关重要,以了解这些影响,以便更好地照顾患者.

科学领域:

神经科学是一个神经科学.
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

由于治疗的进步,癌症的生存率正在增加.
癌症疗法可能会导致不良影响,包括认知功能障碍 ("化学大脑").
当前的研究往往忽略了非神经元细胞在"化学大脑"中的作用.

研究的目的:

探索质细胞有助于化疗诱导的认知功能障碍的假设.
审查涉及"化学大脑"中的质细胞的拟议机制.
发现当前研究中的差距.

主要方法:

关于化疗对中枢神经系统细胞的影响研究的文献综述.
分析涉及微质细胞,星体细胞和寡体细胞的拟议机制.
综合与炎症,神经退行和突触变化相关的发现.

主要成果:

化疗可以导致炎症和由M1微质细胞和A1星体细胞释放的促炎媒介.
A1星球细胞可能会导致神经元退化和兴奋毒性,导致认知障碍.
氧基细胞减少和M1微质激活与髓损伤和神经可塑性降低有关.

结论:

质细胞,包括微质细胞,星球细胞和寡质细胞,都与化疗诱导的认知功能障碍有关.
目前关于化疗对质细胞影响的数据有限.
对质细胞机制的进一步研究对于开发癌症幸存者的治疗策略至关重要.

关键词:

星球细胞是星球细胞.化疗化疗是一种化学疗法.化疗引起的认知障碍化疗引起的认知障碍微质细胞中的微质细胞神经毒性神经毒性氧基质细胞 (Oligodendrocytes) 是一种类型的质细胞.

更多相关视频

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

相关概念视频

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.

Alzheimer's Disease: Treatment

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

Glial Cells

Glial Cells