视网膜和胸膜表型跨新型亚型的2型糖尿病
Kaiqun Liu1, Ting Li2, Pingting Zhong1
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Study Center for Ocular Diseases, Guangzhou, China.
American journal of ophthalmology
|September 5, 2024
概括
2型糖尿病 (T2DM) 亚型显示出明显的长度变化,包括胸膜厚度和质细胞内状层厚度. 微血管损伤与SIDD有关,而SIRD表明早期的神经退行,可能是糖尿病视网膜病变的前身.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- 2型糖尿病 (T2DM) 是异质的,有不同的表型影响疾病的进展和并发症.
- 了解眼睛结构的纵向变化,如胸膜厚度 (CT) 和状细胞内部状层厚度 (GC-IPLT),对于预测T2DM相关的眼睛疾病至关重要.
研究的目的:
- 在2型糖尿病 (T2DM) 患者的不同表型中,研究胸膜厚度 (CT) 和状细胞内层厚度 (GC-IPLT) 的纵向变化.
- 为了确定与不同T2DM亚型相关的特定的眼睛结构变化.
主要方法:
- 一项涉及T2DM患者的前性队列研究,分为五组 (SAID,SIDD,SIRD,MOD和MARD),使用基于β细胞功能和胰岛素耐药性的K-平均集群.
- 扫描源光学连贯性断层扫描用于测量CT和GC-IPLT在基线和4年后的随访.
- 线性混合效应模型被用于评估CT和GC-IPLT在确定T2DM亚型中的绝对和相对变化.
主要成果:
- 在所有T2DM组中观察到CT和GC-IPLT显著下降,随访时间中位数为4.11年.
- 在SIDD和SAID组中出现了最明显的胸膜稀释,而MARD组表现出最慢的稀释率.
- SIRD组显示GC-IPLT损失最大,而SIDD组显示最小,所有变化均具有统计学意义 (P < 0.001).
- 调整后的分析显示,SIDD和SAID的CT稀释速度比MARD更快,SIRD和MARD的GC-IPLT稀释速度更快.
结论:
- 胸膜中的微血管损伤与T2DM的SIDD表型有关.
- 视网膜神经退行早期迹象在SIRD表型中很明显.
- 这些眼部变化可能是糖尿病视网膜病变 (DR) 发展前的早期指标.
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