睡眠质量差,痴呆症状况及其与美国老年成年人全因死亡率的关联
May A Beydoun1, Rio Tate1, Michael F Georgescu1
1Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, Baltimore, MD 21224, USA.
Aging
|September 5, 2024
概括
睡眠质量差与老年人,尤其是男性和白人,在改变生活方式之前死亡风险更高有关. 痴呆症也会增加死亡率,特别是那些睡眠质量更好的人,男性和白人老年人.
科学领域:
- 老年学是指老年学的学科.
- 睡眠医学 睡眠医学
- 神经科学是一个神经科学.
背景情况:
- 睡眠质量,痴呆症和死亡率之间存在关联.
- 这项研究调查了睡眠质量差在痴呆症与死亡率关系中的调解和缓解作用.
- 探讨了性别和种族的双向关联和差异.
研究的目的:
- 检查睡眠质量不佳是否调解或缓解老年美国成年人痴呆症和死亡风险之间的关联.
- 调查反向关联:痴呆症是否调解或缓解睡眠质量和死亡风险之间的关联.
- 为了确定这些关联是否因性别和种族而异.
主要方法:
- 利用了来自健康和退休研究的数据 (N = 6,991,平均年龄 = 78.1岁).
- 采用了考克斯的比例危险模型和四向分解模型来测试相互作用和介导效应.
- 在随访期间 (2006-2020年) 分析了睡眠质量,可能的痴呆症和死亡率之间的双向关联.
主要成果:
- 睡眠质量不佳最初与死亡率增加有关,特别是在男性和白人老年人中,但在完全调整的模型中,这种情况逆转了.
- 可能的痴呆与死亡风险增加两倍有关,特别是在白人成年人中,尽管这种关联在调整后的模型中减弱了.
- 观察到调解和相互作用效应,显著的总效应主要由受控的直接效应驱动. 更好的睡眠质量放大了痴呆症与死亡率的联系.
结论:
- 睡眠质量差与死亡风险有直接关系,在改变生活方式和健康因素之前.
- 痴呆症与死亡率的增加有关,特别是在睡眠质量较好的个体,男性和白人老年人中.
- 需要进一步的研究来阐明推动这些复杂关系的潜在机制.
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