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Updated: Jun 14, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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一个与多巴胺3受体结合的比托普激动剂揭示了一个选择性位点

Sandra Arroyo-Urea1,2, Antonina L Nazarova3,4, Ángela Carrión-Antolí1,2

  • 1Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, Zaragoza, Spain.

Nature communications
|September 5, 2024
PubMed
概括

开发用于氨基基G蛋白结合受体 (GPCRs) 的亚型选择性药物具有挑战性. 比托皮带显示出有前途,这项研究揭示了一个新的结合区域,用于设计针对多巴胺D3受体 (hD3R) 的选择性药物.

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