脂质体输送增强了维生素C在血和白细胞中的吸收:双盲,安慰剂控制,随机化试验
Martin Purpura1, Ralf Jäger2, Ashok Godavarthi3
1Increnovo LLC, 730 E Carlisle Ave, Whitefish Bay, WI, 53217, USA. martin.purpura@increnovo.com.
European journal of nutrition
|September 5, 2024
概括
与标准维生素C相比,脂质体维生素C显著增强了对血和白细胞的吸收.这种脂质体配方为必要的免疫支持提供了更好的生物可用性.
科学领域:
- 营养科学 营养科学
- 生物化学 生物化学
- 药理动力学 药理动力学
背景情况:
- 酸 (维生素C) 对许多生理功能至关重要,包括免疫健康.
- 标准维生素C在胃肠道内表现出有限的稳定性和生物可用性.
- 研究维生素C的增强输送系统对于优化其治疗潜力至关重要.
研究的目的:
- 评估脂肪体维生素C与标准维生素C的比较吸收.
- 为了确定脂质体配方是否能提高维生素C在血和白细胞中的生物可用性.
- 评估人体脂肪体维生素C的药理动力学概况.
主要方法:
- 一项随机,双盲,安慰剂控制的交叉研究,涉及27名参与者.
- 单次500毫克剂量安慰剂,标准维生素C或脂质维生素C的使用.
- 在24小时内连续取血样,以测量血和白细胞维生素C度.
主要成果:
- 与安慰剂相比,标准和脂质体维生素C的血和白细胞度显著增加 (p < 0.001).
- 脂质体维生素C的高峰血度 (Cmax,+27%) 和曲线下的面积 (AUC,+21%) 与标准维生素C相比显著更高 (p < 0.001).
- 与标准维生素C相比,脂质体维生素C的白细胞Cmax和AUC也显著增加 (p < 0.001).
结论:
- 脂质组合的维生素C显著增强了其吸收到血和白细胞.
- 这表明与传统的维生素C补充剂相比,其生物可用性得到改善,并可能具有更高的疗效.
- 脂质体维生素C是优化维生素C在体内供应和利用的有希望的策略.
相关概念视频
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