代谢学分析识别了与心脏功能障碍相关的新代谢物
Kasen L Culler1, Arjun Sinha1, Mallory Filipp2
1Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair St Suite 600, Chicago, IL, 60611, USA.
Scientific reports
|September 5, 2024
概括
代谢变化,如改变葡萄糖和氨基酸代谢,与早期的心脏功能障碍有关. 肌肉中性醇可能在心力衰竭中发挥关键作用,其中包括保留喷射分数 (HFpEF) 的发展.
科学领域:
- 心血管医学 心血管医学
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
背景情况:
- 代谢性并发症 (肥胖,糖尿病) 先于心力衰竭 (HF) 发病,导致亚临床心脏变化.
- 在HF之前驱动心脏功能障碍的特定代谢途径尚不清楚.
研究的目的:
- 为了确定与心脏结构和功能相关的循环代谢物,在高风险的个体中.
- 调查这些代谢物与N-终端B型亲尿素 (NT-proBNP) 水平之间的关系.
- 探索特定代谢物在心力衰竭中的作用,以保存的喷射分数 (HFpEF).
主要方法:
- 在动脉样硬化多民族研究 (MESA) 队列中使用1H-NMR代谢概况 (n=3440).
- 评估了47种代谢物和心脏结构/功能的心声心脏学测量之间的关联.
- 与NT-proBNP水平相关的显著代谢物,并比较HFpEF患者与对照者的代谢物水平.
- 与顶级代谢产物相关的研究基因变异 (mQTLs).
主要成果:
- 十种代谢物,主要与葡萄糖和氨基酸代谢有关,与心脏结构或功能有关.
- 肌化醇,葡萄糖,二甲基硫和肉与较高NT-proBNP相关;d-曼诺斯和与较低NT-proBNP相关.
- 与对照组相比,在HFpEF患者中观察到肌肉内醇水平升高;与肌肉内醇相关的遗传变异增加了NT-proBNP风险.
结论:
- 代谢分析分析揭示了与高风险患者心脏功能障碍相关的新代谢物.
- 这些发现突出了潜在的代谢途径,特别是涉及myo-inositol,与未来的HF风险和HFpEF病原体相关.
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