开发和评估固化超和SNEDDS载有代谢综合征的三重组合疗法
Abdelrahman Y Sherif1, Doaa Hasan Alshora2, Mohamed Abbas Ibrahim2
1Department of Pharmaceutics, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia. ashreef@ksu.edu.sa.
AAPS PharmSciTech
|September 5, 2024
概括
这项研究开发了固化超和自纳米乳化药物递送系统 (SNEDDS),用于联合代谢综合征药物递送. 新的SNEDDS配方显著提高了药物的溶解性和溶解率,为代谢综合征治疗提供了一个有前途的策略.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 代谢综合征需要用于高血压,高血糖和高脂血症的联合治疗.
- 传统的药物配方往往由于溶解性和生物可用性不佳而受到影响.
- 开发有效的药物输送系统对于改善治疗结果至关重要.
研究的目的:
- 开发和优化固化超和自纳米乳化药物递送系统 (SNEDDS),用于同时服用抗高血压,抗高血糖和抗高脂药物.
- 为了提高德沙坦 (CC),基胺 (GB) 和罗斯瓦斯塔丁 (RC) 的可溶性和溶解率.
- 评估开发的SNEDDS配方的药物特性和性能.
主要方法:
- 准备和选各种SNEDDS配方.
- 在SNEDDS和超和SNEDDS中对药物的溶解性研究.
- 使用Syloid吸附剂和PVP-K30.0的优化液体SNEDDS的固化.
- 使用粒子大小分析,泽塔潜力,体外溶解,粉末X射线衍射 (PXRD),里埃形变形红外光谱 (FTIR) 和扫描电子显微镜 (SEM) 的表征.
主要成果:
- 优化的SNEDDS配方 (F6) 由Tween 20:PEG-400:Capmul MCM (4:3:3) 组成,形成了稳定的纳米乳液.
- 添加PVP-K30显著增加了CC和GB的可溶性.
- 液体和固体SNEDDS配方均显著改善了CC,GB和RC的体外溶解率,与纯药物相比.
- PXRD和FTIR证实了固化配方中药物的无形状态.
- 在SEM图像中,液体SNEDDS成功地吸附到Syloid上.
结论:
- 优化的固化超和SNEDDS配方在提高药物溶解性和溶解性方面表现出卓越的性能.
- 这种三重组合的SNEDDS方法为代谢综合征治疗提供了一个有希望的策略.
- 需要进一步的体外实验来证实开发的配方的治疗疗效.
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