脂溶性维生素与美国成年人的代谢综合征之间的关联:来自NHANES数据库的横截面研究
Muxi Li1, Shan Jiang2, Chenxuan Dong3
1College of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150036, China.
BMC endocrine disorders
|September 5, 2024
概括
高水平的维生素A和E与增加代谢综合征 (MetS) 的几率有关,而维生素D则具有保护作用. 对这些脂溶性维生素 (FSVs) 的联合暴露也会增加MetS风险.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 个人脂肪溶性维生素 (FSV) 已知与代谢综合征 (MetS) 有关.
- 关于多个FSV对MetS风险的综合影响的证据有限.
- 由于同时暴露和潜在的协同效应,了解FSV相互作用至关重要.
研究的目的:
- 调查多种FSV的同时暴露与美国成年人发生MetS的几率之间的关联.
- 分析单个FSV (维生素A,E,D) 和MetS成分之间的关系.
- 用先进的统计方法探索剂量反应关系.
主要方法:
- 对NHANES数据 (2003-2006,2017-2018) 的横截面分析.
- 作为暴露物,评估了维生素A (VA),维生素E (VE) 和维生素D (VD) 的血清水平.
- 使用ATP III指南诊断MetS;用于分析的逻辑回归和量子式g计算.
主要成果:
- 较高的血清VA和VE与MetS几率和诸如甘油三和HDL之类的成分正相关.
- 血清VD显示了与MetS的负线性关联,改善了甘油三,血压和葡萄糖.
- 增加FSV共同暴露与13-15%的MetS几率上升有关.
结论:
- 升高的VA和VE水平与更高的MetS风险有关.
- 血清VD显示出对MetS的保护作用.
- 同时暴露于多个FSV增加了发展MetS的可能性.
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