2型糖尿病老年患者骨循环标志物和病之间的关系:一个横截面研究
Shuwu Wei1,2, Xinyu Pan1, Junping Wei3
1Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
BMC endocrine disorders
|September 5, 2024
概括
骨循环标记 (BTM) 与患有2型糖尿病 (T2DM) 的老年患者的糖尿病病 (DKD) 有关. 特定的BTM如25-基维生素D和完整的副甲状腺激素显示与功能和DKD发病率有显著的关联.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 老年病的医生 老年病的医生
背景情况:
- 2型糖尿病 (T2DM) 和骨代谢障碍在老年人群中很普遍.
- 糖尿病病 (DKD) 是T2DM的严重并发症,骨代谢障碍可能会影响其发展.
- 老年T2DM患者骨周转标记 (BTM) 和DKD之间的特定关系需要进一步阐明.
研究的目的:
- 在一大群患有T2DM的老年患者中调查常见的BTM和DKD之间的关联.
- 探索BTMs与功能指标之间的关系,包括尿中的白蛋白与肌素比率 (UACR) 和估计的膜过率 (eGFR).
- 从骨代谢的角度来看,为早期识别患有DKD高风险的人提供基础.
主要方法:
- 一项涉及2051名住院的中国T2DM患者的横截面研究.
- 收集了关于BTMs的数据:25-基维生素D (25-OH-D),β-CrossLaps (β-CTX),骨质素 (OSTEOC),完整的副甲状腺激素 (iPTH) 和总I型原蛋白N终端 (TP1NP).
- 使用回归分析和限制性立方线 (RCS) 曲线分析了与DKD,UACR和eGFR的关联.
主要成果:
- 较高的25-OH-D水平与较低的DKD发病率和UACR相关.
- β-CTX,OSTEOC,iPTH和TP1NP显示与UACR的正相关性和/或与eGFR的负相关性.
- iPTH和OSTEOC与DKD呈现出非线性关联,而25-OH-D显示出线性关系.
- iPTH 和 OSTEOC 显示了具有 DKD 风险的 J 形曲线.
结论:
- 在患有T2DM的老年患者中,BTM与脏疾病有显著的相关性.
- 这些发现可能有助于临床医生在这个人群中制定预防策略和针对DKD的向治疗.
- 骨代谢评估可能是管理老年T2DM患者脏健康的宝贵工具.
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