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在患有严重COVID-19的患者中,循环的microRNA向凝血和纤维素分解

Tuukka A Helin¹, Marja Lemponen², Katariina Immonen³

¹HUS Diagnostic Center, Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, POB 720, Helsinki, 00029, Finland. tuukka.helin@hus.fi.

Thrombosis journal

|September 5, 2024

概括

这项研究表明,COVID-19患者表现出改变的microRNA (miRNA) 概况,影响血液凝固和血小板功能. 这些发现突出了miRNAs作为COVID-19相关血静性障碍的关键参与者.

科学领域:

血液学血液学血液学
分子生物学分子生物学
传染性疾病传染性疾病

背景情况:

众所周知,2019年新冠病毒病 (COVID-19) 会导致严重的凝血障碍.
关于微RNAs (miRNAs) 在COVID-19感染期间调节凝血中的作用的数据有限.

研究的目的:

为了全面分析住院COVID-19患者的miRNA概况.
为了将miRNA表达与凝血标志物和血清参数相关联.

主要方法:

来自40名住院COVID-19患者和10名健康对照者的血样本的分析.
对27种与血栓形成相关的miRNA进行定量逆转录聚合酶链反应 (RT-qPCR).
评估标准凝血测试,·威尔布兰德因子 (VWF),ADAMTS13和血液计数.

主要成果:

与对照组相比,COVID-19患者的特定miRNA水平发生变化,包括增加miR-27b-3p,miR-320a-3p,miR-320b-3p和miR-424-5p,以及减少miR-103a-3p和miR-145-5p.
11个miRNA与血小板数相关,而let-7b-3p与低血红蛋白相关.
几种miRNAs (miR-24-3p,miR-27b-3p,miR-126-3p,miR-145-5p,miR-338-5p) 与VWF水平的升高有关.

结论:

COVID-19患者表现出不同的miRNA表达,影响纤维素分解,凝血和炎症.
这些miRNA变化有助于在COVID-19中观察到的广泛的静血失调,影响血小板,凝血和纤维素分解.

关键词:

血液凝固血液凝固血小板是血液中的血小板.在 COVID-19 疫情中,纤维化解是一种纤维化解.炎症炎症是一种炎症.微RNAs是一种微RNA.

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