新生儿传播HAdV感染的治疗方法的发展
Wenjing Zhang1,2, Fang Liu2,3, Enlin Liang1,2
1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
新生儿人类腺病毒 (HAdV) 感染很罕见,但严重. 早期使用静脉注射免疫球蛋白和葡萄皮质激素的治疗可能会改善HAdV-D病例的结果,并与散布疾病的抗凝血治疗一起.
科学领域:
- 儿科 儿科 儿科
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 新生儿人类腺病毒 (HAdV) 感染不常见,但与显著的多器官系统影响和高死亡率有关.
- HAdV感染可以呈现出各种临床表现,包括新生儿发烧和呼吸困难.
研究的目的:
- 报告新生儿HAdV-D37感染病例及其管理.
- 审查有关新生儿HAdV感染的现有文献,并分析治疗结果.
主要方法:
- 一例新生儿HAdV-D37感染病例是通过血液和支气管支气管洗液上的下一代元基因组测序来诊断的.
- 对41个HAdV病例进行了文献审查,以评估治疗疗效.
主要成果:
- 报告的新生儿患有HAdV-D37感染,发烧和呼吸困难,在用静脉注射免疫球蛋白,甲基prednisolone和抗凝剂治疗后恢复过来.
- 对41例HAdV病例的分析表明,静脉注射的免疫球蛋白可能会改善HAdV-D感染的结果.
结论:
- 静脉注射免疫球蛋白和葡萄糖皮质类药物治疗可能对重症或扩散的新生儿HAdV感染有益.
- 监测凝血和启动抗凝血治疗对于预防传播性血管内凝血等并发症至关重要.
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