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糖尿病状况与急性胰腺炎风险之间的关联:全国性基于人口的研究
Kwang Hyun Chung1, In Rae Cho2, Young Hoon Choi3
1Division of Gastroenterology, Department of Internal Medicine, Soonchunhyang University Hospital Seoul, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.
Journal of evidence-based medicine
|September 6, 2024
概括
急性胰腺炎的风险随着糖尿病的严重程度而增加. 使用胰岛素或多种口服低血糖剂的患者面临的风险较高,相比那些不那么严重的糖尿病.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 糖尿病是一种日益严重的全球健康问题.
- 糖尿病严重程度和急性胰腺炎风险之间的关系尚不清楚.
- 现有的流行病学研究缺乏关于这种关联的最终结论.
研究的目的:
- 调查糖尿病状况与急性胰腺炎风险之间的关联.
- 评估糖尿病严重程度对急性胰腺炎发病率的影响.
- 分析基于大量人口队列中药物使用的风险.
主要方法:
- 利用从健康检查 (2009-2012) 获得的全国人口基队列.
- 包括患有糖尿病的患者,但不包括在检查前或立即检查后患有胰腺炎的患者.
- 分析了口服低血糖剂使用 (<3或≥3) 或胰岛素使用与急性胰腺炎发生之间的关联,直到2018年12月.
主要成果:
- 包括2,444,254名患者;10,360人患有急性胰腺炎.
- 随着糖尿病的严重程度,急性胰腺炎的风险连续增加:口服低血糖剂 <3 (IR=0.546),≥3 (IR=0.665) 和胰岛素使用者 (IR=0.872).
- 调整后的危险比为1.196对于≥3种口服药物和1.493对于胰岛素使用者,这表明风险明显更高.
结论:
- 糖尿病的严重程度与急性胰腺炎的风险增加直接相关.
- 患有更严重糖尿病的患者,特别是那些接受胰岛素治疗的患者,面临着大幅增加的风险.
- 这些发现强调了在胰腺炎风险评估中考虑糖尿病严重程度的重要性.
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