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心脏瘤学的现代方法预防多克索鲁比诱导的心脏毒性:一个系统性审查
Aadi R Palvia1, Abhiram Rao Damera2, Akshay Rahul Nandi3
1Internal Medicine, Kharghar Medicity Hospital, Navi Mumbai, IND.
Cureus
|September 6, 2024
概括
多克索鲁比 (DOX) 化疗可能会导致心脏损伤. 本综述表明,德克斯拉佐,某些RAAS抑制剂,脂质体DOX,以及运动可以预防DOX诱导的心脏毒性,改善患者的治疗结果.
科学领域:
- 瘤学和心脏病学
- 药理学和治疗学 药理学和治疗学
- 心血管毒理学心血管毒理学
背景情况:
- 多克索鲁比 (DOX) 是一种重要的人类环素化疗,可显著改善癌症存活率.
- 对DOX治疗的一个主要限制是其心脏毒性,主要与心肌细胞中反应性氧物种 (ROS) 诱导的线粒体功能障碍有关.
- 预防DOX诱导的心脏毒性对于在癌症治疗期间维持患者的生活质量至关重要.
研究的目的:
- 系统地审查和综合有关预防癌症患者多克索鲁比诱导心脏毒性的干预措施的证据.
- 确定有效的药理和非药理策略,以减轻与DOX化疗相关的心脏损伤.
主要方法:
- 在Google Scholar,PubMed和ScienceDirect数据库上进行系统的文献搜索,遵守PRISMA标准.
- 选标题和摘要,然后检索相关研究的全文.
- 质量评估使用SANRA 2进行叙述性审查,AMSTAR进行系统性审查,以及RCT的Cochrane风险偏差工具.
主要成果:
- 德克斯拉松是一种经过验证的心脏保护剂,可以防止DOX毒性,而不会影响治疗效果.
- 列宁- ангиотензин- алдостерон系统 (RAAS) 抑制剂显示出降低DOX诱导心脏毒性的潜力.
- 非药物干预,特别是运动,以及像白醇和黄素这样的药物,显示出通过抗氧化和抗亡机制减轻心脏损伤的希望.
结论:
- 结合药理和非药理干预的多模式策略对于有效预防DOX诱导的心脏毒性至关重要.
- 用心脏保护药物和生活方式干预措施 (如运动) 补充化疗方案,可以提高治疗效果并降低心脏风险.
- 需要进一步进行强大的临床试验,以巩固各种预防策略的作用,并在接受DOX治疗的患者中优化心脏保护.
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