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相关概念视频

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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The Ras Gene02:38

The Ras Gene

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The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
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RNA Editing02:23

RNA Editing

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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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相关实验视频

Updated: Jun 14, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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人类疾病中的循环RNAs.

Yuanyong Wang1,2, Jin Zhang3,4, Yuchen Yang3,4

  • 1Department of Thoracic Surgery Tangdu Hospital Air Force Medical University Xi'an China.

MedComm
|September 6, 2024
PubMed
概括

循环RNAs (circRNAs) 是参与各种疾病的关键分子. 本综述详细介绍了它们在非癌症和癌症条件中的作用,强调了它们作为诊断生物标志物和治疗点的潜力.

关键词:
生物标志物生物标志物癌症 癌症 癌症 癌症圆形的RNAs是圆形的RNAs.外基因组是外基因组中的一个.预后 预后 预后这是一个渐进的过程.

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Identification of Circular RNAs using RNA Sequencing
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Use of Alu Element Containing Minigenes to Analyze Circular RNAs

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相关实验视频

Last Updated: Jun 14, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

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Identification of Circular RNAs using RNA Sequencing
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Use of Alu Element Containing Minigenes to Analyze Circular RNAs
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科学领域:

  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.
  • 生物化学 生物化学

背景情况:

  • 循环RNAs (circRNAs) 是通过反向拼接形成的,并且越来越多地被认为具有生物学意义.
  • 尽管越来越多的证据表明它们参与了疾病的发病,但对circRNA功能和临床应用的全面理解仍在发展中.
  • 目前关于circRNA功能和应用的现有评论很少,需要进行深入研究.

研究的目的:

  • 提供关于circRNA生物发生,功能和人类疾病中的作用的全面审查.
  • 探索circRNAs在非新发性疾病和各种类型癌症中的参与.
  • 突出circRNAs作为诊断生物标记物和治疗点的潜力.

主要方法:

  • 文献综述和对circRNAs现有研究的综合.
  • 详细检查circRNA参与非新发性疾病 (呼吸道,内分泌,代谢,肌肉骨,心血管,脏) 的情况.
  • 探索circRNAs在瘤中的作用,重点关注癌症发病,进展和治疗抵抗中的外体circRNAs.

主要成果:

  • 循环RNA在各种人类疾病的发病过程中起着重要作用.
  • 外体环RNA是癌症发病,进展和治疗耐药性的关键调解者.
  • 该综述巩固了各种疾病背景中关于circRNA功能的当前知识.

结论:

  • 由于它们参与疾病机制,circRNAs代表了有前途的诊断生物标志物.
  • 循环RNA具有显著的潜力,可以作为非新发性和新发性疾病的新型治疗点.
  • 对circRNAs的进一步研究可以为创新的临床研究和干预措施铺平道路.