相关实验视频

Updated: Jun 14, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

人类疾病中的循环RNAs

Yuanyong Wang^1,2, Jin Zhang^3,4, Yuchen Yang^3,4

¹Department of Thoracic Surgery Tangdu Hospital Air Force Medical University Xi'an China.

|September 6, 2024

概括

循环RNAs (circRNAs) 是参与各种疾病的关键分子. 本综述详细介绍了它们在非癌症和癌症条件中的作用,强调了它们作为诊断生物标志物和治疗点的潜力.

科学领域:

分子生物学分子生物学
遗传学是一个遗传学.
生物化学生物化学

背景情况:

循环RNAs (circRNAs) 是通过反向拼接形成的,并且越来越多地被认为具有生物学意义.
尽管越来越多的证据表明它们参与了疾病的发病,但对circRNA功能和临床应用的全面理解仍在发展中.
目前关于circRNA功能和应用的现有评论很少,需要进行深入研究.

研究的目的:

提供关于circRNA生物发生,功能和人类疾病中的作用的全面审查.
探索circRNAs在非新发性疾病和各种类型癌症中的参与.
突出circRNAs作为诊断生物标记物和治疗点的潜力.

主要方法:

文献综述和对circRNAs现有研究的综合.
详细检查circRNA参与非新发性疾病 (呼吸道,内分泌,代谢,肌肉骨,心血管,脏) 的情况.
探索circRNAs在瘤中的作用,重点关注癌症发病,进展和治疗抵抗中的外体circRNAs.

主要成果:

循环RNA在各种人类疾病的发病过程中起着重要作用.
外体环RNA是癌症发病,进展和治疗耐药性的关键调解者.
该综述巩固了各种疾病背景中关于circRNA功能的当前知识.

结论:

由于它们参与疾病机制,circRNAs代表了有前途的诊断生物标志物.
循环RNA具有显著的潜力,可以作为非新发性和新发性疾病的新型治疗点.
对circRNAs的进一步研究可以为创新的临床研究和干预措施铺平道路.

关键词:

生物标志物生物标志物癌症癌症癌症癌症圆形的RNAs是圆形的RNAs.外基因组是外基因组中的一个.预后预后预后这是一个渐进的过程.

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Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

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