与双酸盐和迪苏马布相关的牙疾病:来自美国食品和药物管理局不良事件报告系统的病例分析
Lei Wang1, Wei Zhang1, Cheng-Long Zhao1
1Department of Pharmacy, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University, Zhengzhou, Henan, China.
Frontiers in endocrinology
|September 6, 2024
概括
双酸盐 (BPs) 和丹诺苏马布与牙疾病有关,包括疼痛和牙周炎. 帕米德罗纳酸显示出最强的关联,强调需要仔细监测这些针对骨的药物.
科学领域:
- 药物监督 药物监督 药物监督
- 口腔医学是指口腔医学.
- 药品安全 药品安全
背景情况:
- 双酸盐 (BPs) 具有抗骨质疏松性质,可能影响牙周病.
- 以前的体外研究表明,BP可以诱导细胞毒性并抑制伤口愈合,可能影响牙周健康.
- 双酸盐和苏马布与牙疾病之间的关系需要进一步调查.
研究的目的:
- 评估双酸盐 (BPs) 和苏马布与牙疾病的相关性.
- 分析美国FDA FAERS数据库中关于牙疾病信号的报道不良事件.
- 评估与药物相关的牙疾病的临床特征和预后.
主要方法:
- 贝叶斯分析和非比例分析应用于美国FDA FAERS数据库.
- 这项研究重点关注了与五种BP和denosumab相关的牙疾病事件.
- 使用标准化的MedDRA查询来确定牙疾病的相关首选术语.
主要成果:
- 共有5863例牙疾病病例与研究中的药物有关.
- 双酸盐和德诺苏马布与牙疾病 (ROR,PRR,IC) 有显著的关联.
- 帕米德罗纳酸呈现出最高的关联 (ROR=64.58),而德诺苏马布显示出最弱的关联 (ROR=3.61). 发现了与牙疼痛,衰退,牙炎和牙周炎的重要联系.
结论:
- 双酸盐和德诺苏马布与各种牙疾病有显著的关联.
- 在研究的双酸盐中,帕米德罗纳酸呈现出最强的相关性.
- 在服用这些药物时,建议对患有牙问题的患者进行持续监测和适当的治疗.
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