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Mutagenicity and Carcinogenicity01:25

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Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
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Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
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分析金属诱导的基因毒性终点

Mohammad Shoeb1, Gregory M Zarus1, Henry E Abadin1

  • 1Office of Innovation and Analytics, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention.

Journal of environmental health
|September 6, 2024
PubMed
概括
此摘要是机器生成的。

和等有毒金属会导致DNA损伤,导致遗传变化. 本综述总结了证据,将金属暴露与基因毒性和表观遗传变化联系起来.

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Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
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科学领域:

  • 环境毒理学环境毒理学
  • 遗传学 是一个遗传学.
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

  • 有毒金属与DNA损伤的启动和进展有关.
  • 接触金属可以激活DNA损伤反应通路.
  • 遗传毒性终点和表观遗传修饰受到金属暴露的影响.

研究的目的:

  • 系统地审查金属诱导的基因毒性证据.
  • 总结 Agency for Toxic Substances and Disease Registry (ATSDR) 的个人资料和文献中的发现. 总结 Agency for Toxic Substances and Disease Registry (ATSDR) 的资料和文献中的发现.
  • 探索金属暴露和DNA变化之间的联系.

主要方法:

  • 系统的文献审查.
  • 对ATSDR毒理学概况的分析.
  • 包括对特定金属的研究:,,,,,,和.

主要成果:

  • 积累的证据表明,金属暴露和基因毒性终点之间存在联系.
  • 接触金属可以诱导全球和基因特异性的DNA变化.
  • 表观遗传修饰也受到有毒金属暴露的影响.

结论:

  • 有毒金属有助于DNA损伤和基因毒性.
  • 需要进一步的研究才能充分理解金属诱导的遗传和表观遗传效应.
  • 对金属暴露风险的公共卫生意识至关重要.