深呼吸深呼吸 保持左侧乳房放射治疗:副作用和成本之间的平衡
Sara-Lise Busschaert1,2, Eva Kimpe1, Thierry Gevaert2
1Research Centre on Digital Medicine, Department of Public Health, Vrije Universiteit Brussel, Brussels, Belgium.
JACC. CardioOncology
|September 6, 2024
概括
深呼吸呼吸 (DIBH) 减少了乳腺癌患者的心血管事件,尽管工作流的影响,但证明具有成本效益. 这种放射治疗技术为幸存者提供了长期的健康益处.
科学领域:
- 辐射瘤学 辐射瘤学
- 心血管健康 心血管健康
- 卫生经济学 卫生经济学
背景情况:
- 深呼吸喘息 (DIBH) 有效地减少心脏辐射暴露在左侧乳腺癌放射治疗.
- 对DIBH采用的重大障碍包括成本和工作流集成的挑战.
研究的目的:
- 评估DIBH与自由呼吸 (FB) 相比,用于治疗左侧乳腺癌的成本效益.
- 评估DIBH与FB的运营,财务和临床结果.
主要方法:
- 用DIBH和FB技术创建了100名患者的治疗计划.
- 用剂量计数据和SCORE2算法来预测心血管风险,估计了心脏毒性.
- 使用微模拟和离散事件模拟模型分析了成本效益和工作流的影响 (吞吐量,等待时间).
主要成果:
- 在20年内,DIBH使心血管事件减少了1.72%,致命事件减少了0.69%,每个患者的QALY为0.04.
- DIBH增加了治疗时间,减少了12.48%的吞吐量,每名患者的费用为617欧元.
- 每个QALY的增量成本效益率为14,023欧元.
结论:
- 尽管治疗时间增加了,但DIBH对于比利时人群来说是一种具有成本效益的放射治疗策略.
- 更广泛地采用DIBH可以改善乳腺癌幸存者的长期心血管健康结果.
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