对前额叶皮层活化和老年女性患有骨关节炎和没有骨关节炎的行走表现的影响:一项FNIRS研究
Alka Bishnoi1, Yang Hu2, Manuel E Hernandez3,4
1Department of Physical Therapy, College of Health Professions and Human Services, Kean University, Union, NJ, United States.
Frontiers in aging neuroscience
|September 6, 2024
概括
乱行走增加了前额叶皮层 (PFC) 在老年妇女的激活,与骨关节炎 (OA) 患者相比,在健康的老年人 (HOA) 中观察到的增加更大. 这表明在步态适应过程中,OA中神经控制机制发生了变化.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物力学 生物力学
背景情况:
- 众所周知,乱行走 (PW) 可以改善步态.
- 了解走路的皮质控制,可以了解患有骨关节炎 (OA) 的老年人的跌倒机制.
- 前额叶皮层 (PFC) 激活是认知和运动控制的关键指标.
研究的目的:
- 调查扰乱行走 (PW) 对前额叶皮层 (PFC) 激活在老年女性和没有骨关节炎 (OA) 的影响.
- 为了比较健康的老年妇女 (HOA) 和患有OA的妇女在PW期间的PFC激活.
- 探索PW期间步态参数,体重指数和PFC激活之间的关系.
主要方法:
- 20名社区老年妇女 (HOA和OA) 参与了这次活动.
- 功能近红外光谱 (fNIRS) 测量了PFC氧化血红蛋白 (HbO2) 和脱氧血红蛋白 (Hb) 在舒适的步行 (CW) 和PW在跑步机上的水平.
- 一个线性混合效应模型分析了队列和任务对PFC激活的影响.
主要成果:
- 在CW和PW任务中,在两个队伍中,PFC激活 (HbO2和Hb水平) 都发生了显著的变化 (P < 0.001).
- 观察到任务和队列之间的显著相互作用 (P <0.05),表明PFC激活模式的差异.
- 增加的姿势时间和体重指数与PW期间PFC激活的减少有关.
结论:
- 乱行走 (PW) 在健康的老年女性 (HOA) 和患有骨关节炎 (OA) 的女性中增加了前额叶皮层 (PFC) 的激活,表明了步态适应.
- 在PW期间PFC激活的增加在HOA中明显高于OA.与OA相比.
- 研究结果表明,OA的老年人中神经激活和运动限制发生变化,需要进一步调查疼痛,肥胖和运动影响.
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