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Updated: Jun 14, 2025

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

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利用生物实验数据和分子动力学来通过机器学习对突变热点进行分类

James G Davies1, Georgina E Menzies1

  • 1Molecular Bioscience Division, School of Biosciences, Cardiff University, Cardiff, CF10 3AX, United Kingdom.

Bioinformatics advances
|September 6, 2024
PubMed
概括

这项研究表明,区域基对旋转和DNA中的GC含量可以预测[a]pyrene二醇氧化物 (BPDE) adduct修复效率. 这些拓特征可以作为突变热点的生物标志物.

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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

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相关概念视频

Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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