关于自然产品在心肌梗塞干预过程中的研究进展
Qiuting Guo1, Jinhui Wang2, Caixia Ni3
1College of Pharmacy, Xianyang Polytechnic Institute, Xianyang, China.
Frontiers in pharmacology
|September 6, 2024
概括
天然药物为治疗心肌梗塞 (MI) - - 一种严重的心脏病 - - 提供了一个有前途的方法. 这些疗法针对多种途径,以减少心脏损伤和改善患者的治疗结果.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 自然产品研究 自然产品研究
背景情况:
- 冠心病,特别是心肌梗塞 (MI),是一个日益严重的全球健康问题,年轻人群中的发病率越来越高.
- 目前用于心脏病发作的临床治疗方法,包括血栓溶解和再血管化,具有局限性,可能导致预后不佳.
- 合成药物的研究局限性正在推动人们对新疗法战略的天然物质的兴趣.
研究的目的:
- 研究心肌梗塞 (MI) 背后的分子机制.
- 在过去五年中评估自然产品和药用植物在心脏病发作治疗中的治疗潜力和应用.
- 突出自然疗法的安全性和有效性,以控制心脏病发作.
主要方法:
- 科学文献的综述,重点关注用于MI治疗的天然产品和药用植物.
- 对过去五年内发表的研究进行分析.
- 研究分子机制,包括氧化应激,炎症,亡等.
主要成果:
- 自然产品显示出显著的治疗潜力和优越的耐受性,用于MI管理.
- 这些自然疗法通过多种机制减轻心肌细胞损伤.
- 确定的途径包括氧化应激,炎症,亡,血管生成,纤维化,自,ER应激,线粒亡和热亡.
结论:
- 天然药物代表了一种新的,更安全,更有效的治疗心脏病的方法.
- 用天然产品准多种致病途径为MI管理提供了一个全面的策略.
- 本综述提供了对基于天然产品的MI疗法的最新见解,有助于预防和治疗策略.
更多相关视频
05:41Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control
Published on: December 16, 2022
3.4K
04:29A Modified Simple Method for Induction of Myocardial Infarction in Mice
Published on: December 3, 2021
3.6K
相关概念视频
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
404
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
404
Antianginal Drugs: Nitrates and β-Blockers
547
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
547
