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Cynomorium songaricum Rupr. 在这里可以看到. 黄类药物通过调节合成途径来改善环胺诱导的生殖功能损伤
Jiarong Chen1, Xiaoyue Yang1, Zhongmei He1,2
1College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Frontiers in pharmacology
|September 6, 2024
概括
在Cynomorium songaricum Rupr.中使用. 黄胺 (CSF) 通过调节性激素和增强类固醇酶表达来保护男性生殖损伤. 这表明CS是男性不孕症的潜在治疗方法.
科学领域:
- 生殖生物学 生殖生物学
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 男性不孕症是一个日益严重的全球健康问题.
- 确定安全有效的治疗方法至关重要.
- 在Cynomorium songaricum Rupr.中使用. (CS) 提取物显示出对生殖健康的前景.
研究的目的:
- 为了研究Cynomorium songaricum Rupr. 的作用. 在男性生殖器损伤方面,黄类药物 (CSF).
- 评估CSF对丸介质干细胞活性的影响.
- 探索涉及丸激素合成途径的潜在机制.
主要方法:
- 在雄性小鼠中使用环胺诱导生殖损伤.
- 管理CSF和评估生殖参数和激素水平 (T,LH,GnRH,FSH,E2) 的评估.
- 在体外研究中使用用双A (BPA) 和CSF治疗的TM3细胞,评估细胞活力和类固醇酶表达.
主要成果:
- 脊髓显著降低了生殖损伤,改善了丸/表皮膜病理.
- 脊髓瘤治疗增加了精液血中的果糖和离子水平.
- 脑脊液增加了血清丸激素,LH,GnRH和FSH,同时降低了雌激素,并在体内和体外增强了类固醇酶的表达.
结论:
- 脑脊液改善了循环胺诱导的生殖功能障碍和BPA诱导的TM3细胞损伤.
- 脑脊液在下垂体-垂体-腺 (HPG) 轴内调节性激素水平.
- CS是男性生殖功能障碍的潜在治疗剂.
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