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一项前性的多中心观察性研究,评估狗中急性输血反应的发病率和风险因素

Georgina B F Hall¹, Rachael Birkbeck², Benjamin M Brainard³

¹Clinical Science and Services, The Royal Veterinary College, London, UK.

Journal of veterinary internal medicine

|September 6, 2024

概括

狗的输血反应发生率为8.9%的红细胞和4.5%的血. 较老的红细胞和较高的剂量增加了输血反应的风险.

科学领域:

兽医医学兽医医学兽医医学
血液学血液学血液学
输血医学输血医学

背景情况:

在兽医中,输血反应 (TR) 的发生率是高度可变的.
需要标准化定义和前性数据来准确评估TR发病率.

研究的目的:

为了前性地评估接受全源血制品的狗中急性TRs的发生率.
为了确定与狗中TRs发生相关的因素.

主要方法:

在美国,英国和澳大利亚的转诊医院进行了一项前性的多中心监测研究.
在2022年3月至11月期间,从858只接受1542种全源血制品的狗中收集了数据.
输血反应根据兽医血液学和输血医学协会 (2021) 的共识指南进行记录.

主要成果:

急性TRs的总发病率为pRBCs的8.9%,而血产品的4.5%.
发烧性非溶血性TRs (FNHTR) 在pRBC中最常见 (4%),而过敏性TRs在血中最常见 (3.2%).
较高的PRBC剂量 (aOR1.04) 和超过28天的储存时间 (FNHTR的aOR4.10,AHTR的OR15.2) 与TR风险增加有关. 白血病减少并没有显著降低TR发病率 (OR 1.47).

结论:

在给狗输血时,临床医生应考虑PRBC的年龄和剂量.
血清细胞的储存时间是与特定输血反应 (如FNHTR和AHTR) 相关的重要因素.
可能需要进一步的研究来调查白血病减少对狗TR发病率的影响.

关键词:

亚特兰大亚特兰大 (AHTRTR) 是一个在 FNHTR 中,FNHTR 是指 FNHTR.在TACOO中使用.特拉利特拉利特拉利特拉利特拉利特狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗在白血病的减少.储存损伤损伤在储存损伤.

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