在自然和医疗辅助生殖中母亲的特征 双胞胎双胞胎妊娠
Nikki Hubers1,2,3, Christian M Page4,5, Lannie Ligthart1
1Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
概括
自然怀孕双胞胎的母亲与通过医疗辅助生殖 (MAR) 怀孕的母亲不同. 自然受孕与更少的流产和更高的母亲年龄,身高和吸烟率有关.
科学领域:
- 生殖生物学 生殖生物学
- 人类遗传学 人类遗传学
- 流行病学 流行病学
背景情况:
- 以前的研究表明,与单双双胞胎和单双双胞胎的母亲相比,自然受孕的双胞胎 (DZ) 双胞胎的母亲表现出不同的特征 (更高,更老,更高的吸烟率).
- 双胞胎母亲的异质性,特别是关于怀孕方法的异质性,尚未完全理解.
- 了解这些差异对于准确的涉及双胞胎的流行病学和遗传学研究至关重要.
研究的目的:
- 调查自然受孕的DZ双胞胎和通过医疗辅助生殖 (MAR) 怀孕的DZ双胞胎之间的母亲特征差异.
- 为了比较不同MAR亚组 (激素诱导与IVF/ICSI) 和自然受孕的DZ双胞胎之间的母亲特征.
- 为了突出双胞胎母亲的异质性,为未来的研究考虑.
主要方法:
- 利用了来自荷兰双胞胎登记册 (NTR) 的33648名母亲和来自挪威母亲,父亲和儿童队列研究 (MoBA) 的1660名母亲的观察调查数据.
- 自然怀孕的DZ双胞胎母亲和MAR怀孕的DZ双胞胎母亲之间的母性特征 (与生育能力相关) 的比较.
- 进一步将MAR母亲细分为激素诱导和IVF/ICSI组进行详细比较.
主要成果:
- 自然怀孕的DZ双胞胎母亲报告说,与MAR DZ双胞胎母亲相比,他们有更多的后代,更高的母亲年龄,更高的身高和更高的吸烟率.
- 自然怀孕的DZ双胞胎母亲的流产次数比MAR DZ双胞胎母亲少.
- 接受荷尔蒙诱导 (OI) 怀孕的母亲比使用试管婴儿/ICSI的母亲有较低的孕妇年龄,更少的流产,以及更多的早产后代.
结论:
- 双胞胎母亲代表了一个异质的群体,基于受孕方法存在显著差异.
- 母亲的特征在自然怀孕和MAR怀孕的DZ双胞胎之间有很大差异.
- 这些发现的差异需要在流行病学和遗传双胞胎研究中仔细考虑.
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