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霍奇金淋巴瘤:2025年关于诊断,风险分层和管理的更新

Stephen M Ansell¹

¹Dorotha W. and Grant L. Sundquist Professor in Hematologic Malignancies Research Chair, Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.

American journal of hematology

|September 6, 2024

概括

霍奇金淋巴瘤 (HL) 是一种罕见的B细胞癌. 对HL的治疗取决于疾病阶段和风险,新的疗法可以改善复发性或耐药性疾病的结果.

科学领域:

血液学血液学血液学
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

霍奇金淋巴瘤 (HL) 是一种不常见的B细胞淋巴状恶性瘤,约占美国所有淋巴瘤的10%.
HL包括两种主要类型:经典HL和结节性淋巴细胞占主导地位的HL,在经典HL内还有进一步的分类.

研究的目的:

概述准确的疾病分期在选择适合HL治疗中的关键作用.
描述预后模型和正电子发射断层扫描 (PET) 扫描在优化HL治疗和识别复发风险.

主要方法:

最初的HL治疗以疾病组织学,解剖阶段和预后因素为指导.
治疗策略从早期疾病的综合模式方法到晚期更长的化疗疗程.
新型药物如布伦图西马布维多丁和抗PD-1抗体是当前前线治疗的组成部分.

主要成果:

高剂量化疗后进行自身干细胞移植 (ASCT) 是复发性HL的标准.
对于对ASCT耐药的患者,治疗选择包括布伦图西马布维多丁,PD-1阻断或全基移植.

结论:

对HL的治疗方法是风险分层的,并且随着新药的加入而不断发展.
复发性或耐药性HL的管理涉及建立的协议,并考虑先进的治疗方法和临床试验.

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