在非透析慢性病患者中,冠状动脉化和心脏结构之间的相关性
Siyi Rao1,2,3, Mengjie Weng1,2,3, Ruoshan Lian1,2,3
1Department of Nephrology, Blood Purification Research Center, First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
ESC heart failure
|September 6, 2024
概括
冠状动脉化 (CAC) 与慢性病 (CKD) 患者的心脏问题和更糟糕的结局有关. 使用心脏超声波的早期检测可以识别那些有严重CAC的高风险的人.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 医疗成像医学成像
背景情况:
- 慢性病 (CKD) 与心血管风险增加有关.
- 冠状动脉化 (CAC) 是动脉样硬化和心血管疾病的标志物.
- 在非透析CKD患者中,CAC和心脏结构/功能之间的关系需要进一步研究.
研究的目的:
- 探索冠状动脉化评分 (CACS) 与非透析CKD患者的心脏结构和功能之间的相关性.
- 使用心脏超声波指标开发严重CAC的临床预测模型.
- 评估CAC对病预后和心力衰竭 (HF) 发展的影响.
主要方法:
- 178名非透析的CKD患者接受了CACS测试.
- 收集了一般信息,血清学指数和心脏超声波发现.
- 对功能,HF表现和重新住院的随访.
主要成果:
- 66.9%的患者患有并发性CAC. 严重的CAC (CACS>100) 与年龄较大,男性性别,吸烟,糖尿病,高血压以及BNP,和纤维素原的升高有关.
- CACS与左心脏直径 (LAD),左心室末端透气直径 (LVDd),左心室体积 (LVVd),中风体积 (SV) 和E/e正相关.
- 严重的CAC增加了HF (1.95x) 和心脏门化 (2.46x) 的风险. LAD,LVDd,HF诊断和膜化预测了严重的CAC. 严重的CAC患者的病预后较差,HF症状较高.
结论:
- 在非透析CKD患者中,CACS和心脏结构/功能之间存在相关性,特别是涉及左心室异常和腹功能障碍.
- CAC对慢性病患者的预后和生活质量产生负面影响.
- 包括HF,膜化和左心室缩指标在内的临床因素可以识别患有严重CAC风险的患者.
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