在运动神经元疾病患者中,胃口切除术后死亡率的预测因素
Jie Yang1,2, Yun Zhao1, Mario Soares1
1Curtin School of Population Health, Faculty of Health Science, Curtin University, Perth, Western Australia, Australia.
Muscle & nerve
|September 6, 2024
概括
在胃口术前显著减肥预测了运动神经元疾病 (MND) 患者的死亡率. 早期的营养支持和及时的胃口术可能会改善MND患者的结果.
科学领域:
- 神经学 神经学
- 胃肠病学 胃肠病学
- 抚慰性护理是一种缓解性护理.
背景情况:
- 运动神经元疾病 (MND) 是一种进展性神经退行性疾病,与有限的预期寿命有关.
- 在MND患者中,胃口切除后30天以后的死亡预测因子存在有限的数据.
研究的目的:
- 调查在MND患者胃口切除术后预测早期死亡率 (30,90和180天) 的人口统计,临床和营养因素.
- 确定胃口切除术后死亡率的关键预测因素,以告知临床护理和管理策略.
主要方法:
- 对94名经过胃口切除术的MND患者 (2015-2021) 的回顾性研究.
- 基于胃口切除术后30,90和180天死亡率的患者组比较.
- 统计分析包括t测试,奇平方测试,费舍尔精确测试和多变量逻辑回归.
主要成果:
- 没有观察到与胃口相关的死亡率.
- 从诊断到胃口术的较大体重减轻 (%) 和较低的强迫生命能力 (FVC) 与30天死亡率有关.
- 90天死亡率的独立预测因素包括年龄较大,男性性别,较低的FVC,不耐受的非侵入性通风和更大的体重减轻 (%).
- 高龄和更大的体重减轻 (%) 是180天死亡率的独立预测因素.
结论:
- 从诊断到胃口术的体重减轻是MND患者90天和180天死亡率的重要预测因素.
- 强调营养护理在管理MND人口中的关键作用.
- 表明,在显著减肥之前进行胃口切除可能会减轻死亡风险,因此需要进一步研究.
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