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血小板与淋巴细胞比率之间的关系和内镜性水结合后的早期再出血:一个双中心的回顾性研究

Wei Wang¹, Honglei Ju¹, Wei Zhang²

¹Department of Gastroenterology, Yijishan Hospital of Wannan Medical College, Wuhu, China.

Annals of medicine

|September 6, 2024

概括

高血小板与淋巴细胞比率 (PLR) 与肝硬化患者内静脉结合 (EVL) 后再出血风险增加有关. 这一发现可能有助于确定那些需要在EVL后进行更密切监测的人.

科学领域:

肝病学肝病学是一种肝病学.
胃肠病学胃肠病学
瘤学 (作为炎症标志物)

背景情况:

内镜静脉结 (EVL) 是肝硬化 (LC) 中食道静脉出血的标准.
经EVL后的复出是严重的并发症,导致超过20%的出血相关死亡.
确定早期再出血的预测因素对于患者管理至关重要.

研究的目的:

为了研究血小板与淋巴细胞比率 (PLR) 与LC患者在EVL后的早期再出血 (在6周内) 之间的联系.
确定PLR是否可以作为EVL后再出血的预测生物标志物.

主要方法:

对两个队列的回顾性分析:宜济山医院 (YJS,n=145) 和福建市第二人民医院 (FY,n=338).
患者接受了首次EVL手术以治疗食道水出血.
用多变量逻辑回归和受限立方线分析来评估PLR与再出血的关联.

主要成果:

在YJS队列中,高PLR独立地与EVL后的早期再出血有关.
限制性立方脊线分析显示,随着PLR的增加,再出血的风险越来越高,停滞在150.0以上.
这些发现在外部财年队列中得到了一致的验证.

结论:

在肝硬化患者中,升高的PLR是EVL后早期再出血的重要预测因素.
测量PLR可以促进识别需要更密切监视的高风险个体.
这种生物标志物可能会改善EVL后的临床决策和患者结果.

关键词:

血小板与淋巴细胞的比率.透镜内性水绑定透镜内性水绑定再次出血的情况.

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