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在需要阴道宫围的妇女中预防妊娠流产的围类型:C-STICH RCT

Victoria Hodgetts Morton^1,2, Catherine A Moakes¹, Jane Daniels³

¹Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.

Health technology assessment (Winchester, England)

|September 6, 2024

概括

这项研究发现,用于宫围的单丝和编织之间在妊娠损失率上没有显著的差异. 两种接类型都在预防流产和早产方面表现出类似的有效性,并提供了可比的安全性.

科学领域:

产科和妇科产科和妇科
孕产妇和胎儿医学孕产妇和胎儿医学
手术创新在外科创新.

背景情况:

第二季度流产和早产是全球重要的健康问题.
手术性宫 cerclage 是一个常见的干预措施,以防止流产.
编织线可能会增加由于细菌殖民的感染风险的假设需要调查.

研究的目的:

为了比较单丝与织接材料在接受阴道宫围的妇女中预防怀孕流产的有效性.
评估与早产预防有关的二次结果.

主要方法:

一个优越性开放的随机受控试验,涉及75个英国产妇中心的2049名妇女.
参与者被随机分配1:1接受单丝或编织的宫 cerclage.
主要结局是怀孕流产 (流产和围产死亡率);次要结局包括早产.

主要成果:

分析了单丝组的1005名妇女和编织组的993名妇女的数据.
在单丝 (80/1003) 和编织 (75/993) 组之间没有观察到妊娠损失率的统计学上显著差异.
妊娠损失的调整后风险比为1.05 (95% CI:0.79至1.40).

结论:

该研究没有发现证据支持用于宫 cerclage 用的单丝和编织接材料之间的怀孕损失率的差异.
在这种情况下,这两种 suture 类型在预防妊娠流产方面似乎同样有效.
在试验期间,没有发现安全问题.

关键词:

在怀孕期间怀孕的第三个月过早出生的孩子.随机对照试验随机对照试验第二季度的错误表现这些女都是娘.阴道宫宫的使用.

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