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在一次和多次给16名接受梯形切除术的患者后,手中的局部 cefuroxime 组织度:随机对照试验

Andrea René Jørgensen¹, Pelle Hanberg², Mats Bue³

¹Aarhus Denmark Microdialysis Research Group (ADMIRE), Orthopaedic Research Unit, Aarhus University Hospital, Aarhus; Department of Clinical Medicine, Aarhus University, Aarhus.

Acta orthopaedica

|September 6, 2024

概括

与单次剂量相比,重复服用塞福洛キシ姆显著扩大了手部组织中的抗生素覆盖范围. 这确保了较长的外科手术过程中足够的抗微生物水平,改善了患者的治疗结果.

科学领域:

整形外科手术整形外科手术
药理动力学药理动力学
预防传染病预防传染病

背景情况:

在手术中抗生素预防的持续时间还不清楚.
塞福洛キシ姆在手部组织中的有效性需要进一步研究.

研究的目的:

为了确定在手部组织中低于4μg/mL的最小抑制度 (MIC) 的度的持续时间.
为了比较单次和重复的塞福洛キシ姆给药.

主要方法:

一项前性随机研究,涉及16名接受梯形切除术的患者.
微透析导管放置在甲手腕骨,突膜和皮下组织中.
患者接受单剂量或两剂四小时间隔的黄素 (1,500毫克) 剂量.

主要成果:

重复使用塞福洛キシ姆可显著延长甲手骨中MIC (4μg/mL) 以上的时间 (平均差异为199分钟).
在突和皮下组织中观察到类似的趋势.
单次的塞福洛キシ姆剂量提供至少3小时59分钟的覆盖.

结论:

重复服用素可以在手部组织中提供更优质和更持久的抗菌覆盖.
为了充分覆盖切口,应在切口前至少27分钟给药塞福洛キシ姆.
在超过4个小时的手术中,请考虑重新给药 cefuroxime.

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