重复未诊断的甲状腺结节:两个甲状腺诊所的经验
Filippo Egalini1, Mattia Rossi2, Chiara Mele3
1Unit of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy - filippo.egalini@edu.unito.it.
Minerva endocrinology
|September 6, 2024
概括
重复非诊断的甲状腺结节 (RNDNs) 显示出非常低的恶性瘤率,通常是良性. 对于这些RNDN,可以考虑采用临床超声波监测方法.
科学领域:
- 内分泌学 在内分泌学.
- 细胞病理学 细胞病理学
- 放射学 放射学是一门学科.
背景情况:
- 重复非诊断性甲状腺结节 (RNDNs) 的临床治疗缺乏高质量的证据.
- 讨论了关于RNDN的当前建议和实践.
- 这项研究旨在描述RNDNs并评估其管理.
研究的目的:
- 为了表征反复的非诊断性甲状腺结节 (RNDNs).
- 评估RNDNs的临床管理.
- 评估恶性瘤风险和RNDNs的最佳后续策略.
主要方法:
- 来自意大利两所学术医院的319名RNDNs (TIR1) 患者的回顾性观察研究 (2016-2020).
- 收集了超声波 (美国) 引导细针吸收细胞学 (FNAc) 数据.
- 细胞学样本和美国检查被病理学家和内分泌学家审查.
主要成果:
- 低基因结节有更高的风险成为RNDNs (OR=1.727).
- 在不到10年前识别的结节的风险较低 (OR=0.349).
- 只有16名RNDNs接受了手术,发现了3种恶性瘤,所有这些都具有高风险的美国特征和第三个FNAc上的TIR3B结果.
结论:
- 在现实环境中,RNDN的恶性瘤率非常低,通常代表具有回归变化的良性喉.
- 对于RNDNs,可以谨慎考虑采用临床超声监测方法.
- 较大的结节和具有较高美国风险的结节 (EUTIRADS 4-5,AACE/AME中等/高风险) 需要更加关注.
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