在癌症预防研究-II中,睡眠和癌症死亡率
Sidney M Donzella1, Emily Deubler2, Alpa V Patel2
1Department of Epidemiology, University of Washington, 380 15th Ave NE, Seattle, WA, 98195, USA. Sdonzell@fredhutch.org.
Cancer causes & control : CCC
|September 6, 2024
概括
睡眠时间影响癌症死亡风险,特别是在男性中,短时间和长时间的睡眠都会增加肺癌和结直肠癌的风险. 然而,感知到的失眠与总体较低的癌症死亡风险有关.
科学领域:
- 流行病学 流行病学
- 睡眠科学 睡眠科学
- 在瘤学瘤学.
背景情况:
- 睡眠是影响癌症结果的关键因素.
- 以前的研究还没有完全探索睡眠和癌症死亡率之间的性别和特定地点的关联.
- 了解这些关系对于公共卫生和癌症预防策略至关重要.
研究的目的:
- 调查睡眠时间,感知失眠和癌症死亡率之间的关联.
- 检查这些关联如何根据性别和特定癌症部位而有所不同.
- 分析癌症预防研究II.II.中的大量队列数据.
主要方法:
- 在癌症预防研究II中利用了983,105名美国无癌症成年人的数据,其中包括1982年收集的睡眠数据.
- 追踪到2018年的癌症特定死亡率.
- 采用多变量Cox比例危险模型,按性别分层,以确定危险比率和置信区间.
主要成果:
- 短 (6小时) 和长 (8-14小时) 的睡眠时间与与7小时相比,整体癌症死亡率的风险增加2-5%.
- 观察到睡眠时间和癌症死亡率之间的显著非线性趋势,特别是在男性中.
- 睡眠时间短/长的男性显示肺癌死亡风险增加;长时间睡眠与更高的结直肠癌死亡风险有关. 感知到的失眠与总体癌症死亡风险降低3-7%相关.
结论:
- 睡眠时间和感知到的失眠是性别和特定癌症死亡率的重要因素.
- 这些发现强调了在癌症研究和临床实践中考虑睡眠模式的重要性.
- 需要进一步研究其他睡眠成分及其与癌症死亡率的关系.
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