在结核病治疗药物监测
1Department of Pulmonary Medicine, Indira Gandhi Medical College, Shimla, 171001, Himachal Pradesh, India. drsarkarmalay23@rediffmail.com.
European journal of clinical pharmacology
|September 6, 2024
概括
治疗药物监测 (TDM) 通过个性化药物剂量优化结核病 (TB) 治疗. 这种方法改善了患者的治疗结果,并降低了耐药性和毒性的风险.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 抗结核药物的药理动力学变异导致治疗结果差,并导致药物耐药性.
- 治疗药物监测 (TDM) 对于优化药物剂量和改善结核病 (TB) 患者管理至关重要.
研究的目的:
- 审查结核病药物的药理动力学和药理动力学.
- 讨论结核病管理中的TDM的指示,方法和解释.
- 突出TDM在解决治疗反应不佳和药物毒性方面的作用.
主要方法:
- 从PubMed,Embase和CINAHL的文献进行了叙事审查.
- 搜索术语包括结核病,TDM,抗结核药物,药理动力学和药理动力学.
- 所有的文章类型都被选中加入.
主要成果:
- TDM在治疗结核病方面是有效的,特别是在缓慢反应,耐药性和复发性感染的情况下.
- 对于患有糖尿病和艾滋病毒感染等并发症的患者来说也有益.
- TDM有助于识别和管理药物毒性和相互作用.
结论:
- 治疗药物监测 (TDM) 显著改善了结核病患者的治疗结果.
- TDM有助于缓解获得药物耐药性的发展.
- 实施TDM可以有效地减少药物不良影响的发生率.
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