怀孕期糖尿病的终身病史和中年妇女的认知功能
Diana C Soria-Contreras1, Siwen Wang2, Jiaxuan Liu3
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. dsoria@hsph.harvard.edu.
Diabetologia
|September 6, 2024
概括
孕期糖尿病 (GDM) 病史的女性经历中年认知功能较差,特别是在精神运动速度和全球认知方面. 这凸显了潜在的风险和早期干预策略的必要性.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 孕期糖尿病 (GDM) 影响了大量的怀孕.
- 包括认知影响在内的GDM的长期健康后果需要进一步调查.
研究的目的:
- 调查妊娠糖尿病史与中年女性认知功能之间的关联.
- 探索2型糖尿病作为这种关系中介者的作用.
主要方法:
- 对前性护士健康研究II的二次分析,包括15,906名孕妇.
- 使用Cogstate简要电池测量精神运动速度/注意力,学习/工作记忆和全球认知的认知评估.
- 线性回归模型对多个共变量进行调整,以估计认知功能差异.
主要成果:
- 与没有GDM的女性相比,有GDM史的女性在心理运动速度/注意力和全球认知方面的表现较低.
- 这些认知缺陷在调整各种人口和怀孕前因素后被观察到.
- GDM与认知衰退之间的关联部分是由随后发展的2型糖尿病介导的.
结论:
- 患有GDM史与中年时认知功能较差有关.
- 研究结果表明,GDM是潜在的认知障碍风险因素.
- 对患有GDM的女性早期风险修改策略的进一步研究是有必要的,以减轻认知能力下降.
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