在人体基础动脉的活体变形
Jaemin Kim1, Kaiyu Zhang2, Gador Canton2
1James T. Willerson Center for Cardiovascular Modeling and Simulation, The Oden Institute for Computational Engineering and Sciences and the Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Annals of biomedical engineering
|September 6, 2024
概括
一种新的MRI方法测量了人体基底动脉 (BA) 壁的运动,揭示了复杂的变形. 这可以改善对神经血管机制的理解,并帮助对内动脉瘤的临床决策.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 神经血管力学 神经血管力学
背景情况:
- 内动脉瘤影响数以百万计的人,破裂带来重大风险.
- 目前的破裂风险得分具有有限的临床效用.
- 动脉壁运动是神经血管健康的一个有前途的生物标志物.
研究的目的:
- 开发和验证一种新的体内MRI方法,用于评估人类基底动脉 (BA) 壁的运动和应变.
- 分析心脏周期中BA变形的区域和时间变化.
- 探索该方法在改善内动脉瘤临床决策方面的潜力.
主要方法:
- 开发了一种新的 in vivo MRI 技术,以捕捉人类基底动脉的心脏门图像.
- 分段内光表面以创建高分辨率的点云.
- 采用基于B-spline的表面表征来导出局部异构型壁系.
主要成果:
- 在BA壁变形中表现出明显的区域和时间变化.
- 观察到大的环形菌株 (高达20%) 和较小的,经常收缩的纵向菌株.
- 在心脏周期中确定了BA的异步变形,由时间相滞后证明.
结论:
- 拟议的MRI方法允许对基底动脉进行详细的局部变形分析.
- 这些发现突显了BA功能的异质和异步性质.
- 将这种方法与现有的分数相结合,可以提高对BA机制和对内动脉瘤的临床决策的理解.
相关概念视频
Blood Flow
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
Overview of the Heart
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
The heart's structure...
Heart Valves
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Structure of Blood Vessels
Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
Arteries of Lower Limbs
The external iliac artery transitions out of the body cavity, entering the femoral region of the lower leg, and is renamed the femoral artery at the point where it traverses the body wall. This artery is responsible for the distribution of blood to the thigh's deep muscles and the skin's ventral and lateral regions, achieved through several minor branches and the lateral deep femoral artery, which also spawns a lateral circumflex artery. The knee area receives blood from the genicular artery,...
Anatomy of Blood Vessels
The vascular system, an integral part of the circulatory system, comprises various blood vessels that play crucial roles in maintaining the body's homeostasis. These blood vessels form a complex and efficient circulatory network. The three primary categories of blood vessels are the arteries, veins, and capillaries.
Arteries
Arteries circulate oxygenated blood from the heart, except the pulmonary artery, which transports deoxygenated blood to the lungs. Large arteries, such as the aorta, have...
Arteries
Arteries circulate oxygenated blood from the heart, except the pulmonary artery, which transports deoxygenated blood to the lungs. Large arteries, such as the aorta, have...


