长期COVID和垂体功能障碍:一种双向关系?
Luigi di Filippo1, Vincenzo Franzese2, Simona Santoro2
1Institute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy. difilippo.luigi@hsr.it.
Pituitary
|September 6, 2024
概括
长期的COVID可能源于影响下丘脑-垂体轴,特别是上腺轴的荷尔蒙失衡. 这篇评论探讨了这些荷尔蒙功能障碍及其对长期COVID患者的影响.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 病理生理学 病理生理学
背景情况:
- 长期COVID是SARS-CoV-2感染后的综合征,显著影响患者的生活质量.
- 长期COVID的潜在病理生理学仍然不太清楚,荷尔蒙失调被认为是关键因素.
- 垂体下垂体轴的变化越来越多地与长期COVID症状的发展和持续有关.
研究的目的:
- 审查和讨论在长期COVID中下丘脑-垂体轴中的荷尔蒙功能障碍的作用.
- 突出这些内分泌变化的潜在负面影响,这些内分泌变化对长期COVID综合征.
- 综合当前关于COVID-19幸存者的垂体功能的证据.
主要方法:
- 在长期COVID和COVID-19幸存者中调查激素轴的研究文献综述.
- 关于下丘脑-垂体-上腺 (HPA) 轴,下丘脑-垂体-腺 (HPG) 轴,下丘脑-垂体-甲状腺 (HPT) 轴和下丘脑-生长激素 (GH) 轴的数据分析.
- 综合与中央上腺功能不充分,下腺,甲状腺功能低下和GH缺乏相关的发现.
主要成果:
- 在长期COVID中,HPA轴经常受到损害,导致亚临床中央上腺功能不充分.
- 在康复后几个月的COVID-19幸存者中观察到的中央性阴性腺的高患病率.
- 据报道,下丘脑-GH轴损伤,而HPT轴在幸存者中似乎在很大程度上保留了.
结论:
- 激素功能障碍,特别是涉及垂体腺,可能代表长期COVID的显著病理生理机制.
- 这些发现表明长期COVID的潜在垂体中心视图.
- 需要进一步的大规模临床研究来证实这些对诊断和治疗的影响.
关键词:
上腺功能不充分的情况.在 COVID-19 疫情中,生长激素缺乏,生长激素缺乏.催产素缺陷症是什么 催产素缺陷症缺陷性脑垂体主义 (hypopituitarism) 是一种长时间的COVID.下垂体 - - 下垂体这就是SARS-CoV-2病毒.更多相关视频
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
22.4K
09:48Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
Published on: February 25, 2022
4.0K
相关概念视频
01:37Hypothalamic-Pituitary Axis
59.7K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.7K
01:27Psychoneuroimmunology: Cardiovascular Disease
27
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
27
01:17The Pituitary Gland
6.5K
The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
6.5K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
01:30Stress and Mental Health
88
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
88
01:19Psychoneuroimmunology: Diabetes and Cancer
27
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
27