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细胞质hPGK1的酸化影响蛋白质稳定性和连接体结合:对其在癌症中的亚细胞向的影响

Juan Luis Pacheco-García1, Mario Cano-Muñoz1, Dmitry S Loginov2

  • 1Departamento de Química Física, Universidad de Granada, Spain.

The FEBS journal
|September 6, 2024
PubMed
概括

在S256中对人类糖酸酶1 (hPGK1) 的酸化使酶不稳定,降低了Mg-ADP的结合亲和力. 这种蛋白质稳定性变化可能会增强hPGK1在癌症中的核转位.

关键词:
癌症 癌症 癌症 癌症 癌症带结合的结合方式酸甘油酸酶激酶是一种酸甘油酸.蛋白质的酸化是蛋白质的酸化.蛋白质的稳定性 蛋白质的稳定性

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