在高风险人群中减少尼古丁香烟和电子烟:3项随机临床试验
Stephen T Higgins1, Stacey C Sigmon1, Jennifer W Tidey2
1University of Vermont Tobacco Center of Regulatory Science, University of Vermont, Burlington.
减少香烟中的尼古丁 (VLNC) 和提供首选的电子烟口味显著降低了风险成年人的吸烟和有毒物质暴露. 这种方法对公共卫生干预有希望.
科学领域:
- 公共卫生 公共卫生
- 控制烟草的控制方式
- 成 药物 药物 药物 药物
背景情况:
- 对电子烟的香味禁令可能会阻碍成年人戒烟.
- 患有精神疾病或低学历的成年人继续吸烟的风险更高.
研究的目的:
- 为了比较使用单独使用非常低尼古丁含量 (VLNC) 香烟,使用烟草口味电子烟或使用首选口味电子烟的风险成年人吸烟减少.
- 评估风味偏好对戒烟结果的影响.
主要方法:
- 三项随机临床试验涉及326名不打算戒烟的每日吸烟者.
- 参与者被分配到普通尼古丁含量 (NNC) 香烟,VLNC香烟,VLNC香烟与烟草风味电子烟 (VLNC + TF) 或VLNC香烟与首选风味电子烟 (VLNC + PF).
- 主要结局是16周每天吸烟的香烟 (CPD);次要结局包括与烟草有关的生物标志物,如NNAL.
主要成果:
- 与NNC (22.54),VLNC (14.32) 和VLNC + TF (11.76) 相比,VLNC + PF显著降低了CPD (7.63),这与NNC (22.54),VLNC (14.32) 和VLNC + TF (11.76) 相比.
- 在VLNC + PF组中,NNAL水平最低,这表明有毒物质暴露减少.
- 与NNC相比,单独的VLNC香烟和带有烟草风味的香烟也减少了CPD.
结论:
- 低尼古丁香烟 (VLNC) 可以减少高风险人群的吸烟和毒素暴露.
- 与VLNC香烟一起提供首选的电子烟风味可以增强这些积极影响.
- 这一战略有可能在烟草控制方面进行有效的公共卫生干预.
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