微纳米塑料和心血管疾病:证据和观点
Francesco Prattichizzo1, Antonio Ceriello1, Valeria Pellegrini1
1IRCCS MultiMedica, Polo Scientifico e Tecnologico, Via Fantoli 16/15, 20138 Milan, Italy.
European heart journal
|September 6, 2024
概括
微和纳米塑料 (MNP) 颗粒可能是一个新的心血管疾病 (CVD) 风险因素. 有证据表明,MNP在人体心血管组织中积累,并与心血管疾病事件的增加有关,需要进一步研究和减少塑料使用.
科学领域:
- 环境健康 环境健康
- 心血管科学 心血管科学
- 毒理学 毒理学 毒理学
背景情况:
- 化学物质暴露越来越被认为是心血管疾病 (CVD) 的环境驱动因素.
- 由塑料降解而产生的微和纳米塑料 (MNP) 颗粒正在成为潜在的新型心血管疾病风险因素.
- 临床前研究表明,MNP可以诱导氧化应激,炎症和细胞衰老,导致心血管和代谢功能障碍.
研究的目的:
- 审查和综合目前关于微型和纳米塑料 (MNP) 颗粒在心血管疾病 (CVD) 中的作用的证据.
- 突出人类心血管组织中MNP的存在及其与心血管事件的关联.
- 确定关键的研究差距和未来方向,以了解MNP在心血管疾病中的因果作用.
主要方法:
- 来自临床前模型的实验数据的审查.
- 对检测心血管组织和血栓中MNP的人类研究的分析.
- 关联研究将MNP在动脉斑块中的存在与心血管事件联系起来.
主要成果:
- 在人类动脉样硬化斑块,心周和脂肪组织,心肌和左心房附属物中检测到MNP.
- 在血管损伤和血栓中积累MNP,在心动脉斑块中存在,与心血管事件发生率增加有关.
- 临床前数据表明,MNP诱导了与心血管疾病相关的关键病理机制,包括氧化应激和炎症.
结论:
- 人类心血管组织中存在MNP,并与不良心血管结果相关,这表明MNP可能在心血管疾病中起因作用.
- 需要进一步的研究来阐明MNP的吸收,积累,剂量反应关系以及心血管疾病中精确的病理生理机制.
- 建议减少塑料生产和使用,可能通过联合国全球塑料条约等国际协议,以获得环境和人类健康的好处.
相关概念视频
Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...


