马类喘与气管洗中的真菌元素之间的关联:与环境匹配的病例控制研究
Sarah Dély1, Vinzenz Gerber1, Laureen M Peters2
1Vetsuisse Faculty, Department of Clinical Veterinary Medicine, Swiss Institute of Equine Medicine (ISME), University of Bern, Bern, Switzerland.
PloS one
|September 6, 2024
概括
气管洗中的真菌存在与马类喘无关. 然而,呼吸道中的粘液增加显著增加了马的喘几率.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 马的呼吸系统健康 马的呼吸系统健康
- 菌类学 菌类学是指菌类学.
背景情况:
- 在气管洗 (TW) 中存在的真菌被认为是导致马类喘的因素.
- 然而,增加的真菌检测也可能是由于喘马的粘液清除变化或环境因素造成的.
研究的目的:
- 调查TW中的真菌存在与马匹喘状况之间的关联.
- 控制混因素,包括环境暴露,粘液积累和细胞学特征.
主要方法:
- 对73匹马 (39匹喘,34匹对照) 进行了回顾性病例对照研究,并根据马进行匹配.
- 马经历了临床评分,内镜,TW和支气管支气管洗 (BAL).
- 多变量逻辑回归被用来分析喘状况和TW真菌之间的关联,考虑粘液得分和多核巨细胞 (MGCs) 具有不同的定义.
主要成果:
- 气管粘液评分≥2与患喘的可能性增加了3.6至4.3倍.
- 在TW中存在的真菌元素和马类喘状况之间没有发现任何关联.
- 没有其他检查的变量与喘或TW真菌检测有显著的关联.
结论:
- 气管粘液的积累是马类喘的重要危险因素.
- 气管洗中真菌的存在与马类喘没有直接关联,这挑战了以前的假设.
- 进一步研究马匹喘的发病因应应侧重于粘液清除机制.
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