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Updated: Jun 14, 2025

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

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通过调节p38激活,PIK-III在激活的纤维细胞中发挥抗纤维性作用

Santiago Sanchez1, Aaron K McDowell-Sanchez1, Sharaz B Al-Meerani1

  • 1Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, United States of America.

PloS one
|September 6, 2024
PubMed
概括

化合物PIK-III通过抑制纤维细胞激活和p38信号传递,在全身性硬化症 (SSc) 中表现出强大的抗纤维素作用. 这种新的治疗方法在临床前模型中显著减少了皮肤和肺组织纤维化.

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