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在多发性骨髓瘤患者中COVID-19的风险评估和临床影响:系统性审查和元分析

Sultan Mahmud¹, Md Faruk Hossain², Abdul Muyeed³

¹Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

|September 6, 2024

概括

COVID-19显著影响多发性骨髓瘤 (MM) 患者,住院率高 (53%) 和死亡率高 (22%). 诸如年龄和肥胖等因素影响了结果,突出了对量身定制护理的需要.

科学领域:

血液学血液学血液学
传染性疾病传染性疾病
在瘤学瘤学.

背景情况:

多发性骨髓瘤 (MM) 患者对感染的易感性增加,包括严重的COVID-19.
这一系统性审查是首次全面评估COVID-19对MM患者的影响.

研究的目的:

系统地审查和元分析COVID-19在多发性骨髓瘤患者的结果.
确定导致MM患者COVID-19结果异质性的因素.

主要方法:

遵守PRISMA指南和PROSPERO注册 (CRD42023407784) 的要求.
在PubMed,EMBASE和科学网络上进行系统的文献搜索 (2020年1月至2024年4月).
使用JBI关键检查清单进行质量评估;通过Egger的测试和漏斗图进行出版偏差评估;用于数据合成的随机效应模型.

主要成果:

医院住院率: 53% (I2=99%),ICU入院率: 17% (I2=94%),死亡率: 22% (I2=97%),生存率: 78% (I2=97%). 医院住院率: 53% (I2=99%),ICU入院率: 17% (I2=94%),死亡率: 22% (I2=97%),存活率: 78% (I2=97%). 医院住院率: 53% (I2=99%),ICU入院率: 17% (I2=94%),死亡率: 22% (I2=97%),存活率: 78% (I2=97%). 医院住院率:
在研究中观察到显著的异质性.
超回归揭示了研究类型,人口统计学 (年龄>67岁) 和并发症 (肥胖) 显著影响了结果. 老年患者的死亡率增加了15%,肥胖患者的死亡率增加了33%.

结论:

在多发性骨髓瘤患者中,COVID-19呈现出不同的结果.
结果的异质性很大,受研究设计,患者人口统计和并发症的影响.
研究结果强调了影响MM中COVID-19结果的因素的复杂相互作用,需要个性化管理策略.

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